ࡱ> Q  bjbj eieitM~ ~ 4DDDhHD,:.^t n"#\*,,,,,,,,,,,,,$.g1nP,#R "t ##P,e,2(((#j*,(#*,((*&+ٙ&\$j*,,<,*,1$r1&+1&+##(#####P,P,8&h###,####1#########~ X : ԰Ƶ Biological Safety Advisory Group Proposal and Risk Assessment for Categorisation of a Procedure Involving Work with Genetically Modified Animals Guidance for completing risk assessments on genetically modified organisms can be found on the HYPERLINK "/hso/hsoatoz"University (Biological safety section) and  HYPERLINK "https://www.hse.gov.uk/biosafety/gmo/acgm/acgmcomp/index.htm" HSE websites. Submit completed forms to HYPERLINK "mailto:safetyscienceschools@sussex.ac.uk"safetyscienceschools@sussex.ac.uk. Completed forms must be reviewed by the Schools Biological Safety Officer (BSO). If the work is GM class 2 or above it additionally needs to be reviewed by the Biological Safety Advisory Group (BSAG). This must be completed prior to any material being received onto site. Where risks are identified, detail how they will be managed by engineering (building/infrastructure) and procedural (training) controls. Please provide a proportionate level of information to the risk posed by the work and avoid one word/short answers. Project title:  Principal investigator/ Responsible person:School and Department:Location of work - building(s) & room number(s):Date of first application:Date of current review: Section 1: Personnel Briefly indicate your experience of working with microorganisms, animals and genetically manipulated organisms and any training you have received.  Other workers on the project [if known]QualificationsExperience/Training  Section 2: Project Description of the project, including the methods to be used and the purpose of the genetic modification. Provide details of the host organism that will be used Provide details of the vector system that will be used Origins and intended function of the genetic material involved  Section 3: Risk Assessment This section should include the justifications for any assessments made and sufficient detail to support them. Level of risk must be estimated using the matrix in appendix 1. Section 3A: Assessment for environmental harm What is the capacity of the GMO to survive, establish, disseminate with and/or displace other animals, and have adverse effects on animals and plants? Level of risk:  What is the potential for transfer of genetic material between the GMO and other organisms? Level of risk:  What is the potential for harmful effects from the products of gene expression? Level of risk:  What is the potential for harmful effects from phenotypic or genetic instability? Level of risk:  What is the potential for harmful effects from the animals acting as novel animal disease vectors? Level of risk:  Based on the risk to the environment (3A) assign the required containment level: 1 2 3 4 (Circle as appropriate) Section 3B: Human health and safety What are the hazards to human health and safety posed by the GM animal? (e.g. toxicity, allergenicity, behavioural, human disease reservoir) Level of risk:  Section 3C: Classification/Containment Based on the risk to human health (3B) assign the required containment level: 1 2 3 4 (Circle as appropriate) Based on the likelihood of environment harm (3A) and risk to human health (3B), assign the required GMO activity class: 1 2 3 4 (Circle as appropriate) Section 4: Control Measures to Be Employed Provide details of all containment and control measures required to contain the identified hazards to the environment and to human health and any means by which their effectiveness will be monitored. This must include details of: known potential route(s) of environmental release and whether these are properly managed. the inactivation procedures to be employed for waste contaminated with GMOs. the expected degree of inactivation/kill and any appropriate validation procedures.  Section 5: Emergency Planning Does your risk assessment(s) provide adequate protection and provision for emergency action in case of accidental release? If no, give details of specific extra safety measures which will be applied to the project.Yes / No  REQUIRED SIGNATURES Signatures need to be collected in the order they appear below. Only sign once you have completed the task you are responsible for and conveyed any necessary improvements/advice to the Principal Investigator/Responsible Person. If the work is class 2 or above then it must be reviewed by the BSAG. If there is a query regarding any GMO project please do not hesitate to contact your BSO or the BSAG. Name: Signed: Date: (School Biological Safety Officer to confirm the risk assessment has been reviewed and the labs where the work will be undertaken have been inspected to ensure they are operating at the required containment level) Name: Signed: Date: (Chair Biological Safety Advisory Group to confirm they have reviewed the risk assessment. When the work is deemed to be class 2 or above the risk assessment must be reviewed by the BSAG. In this situation, the Chair is signing on behalf of the BSAG) Name: Signed: Date: (Head of School to confirm they are aware of the work and the review process complies with the Schools health and safety requirements.) Control measures and risk classification detailed in this application approved by: Name: Signed: Date: (Principal Investigator/Responsible Person also signing to confirm that all workers are trained and competent) Appendix 1: Matrix for estimation of risk Likelihood x Severity = Score  Confirmation of reading and understanding of GMO risk assessment [insert project title] (File = [insert file name]) NameSignatureDate     GMO Risk Assessment PAGE 1 H&S Document NoSSHS F043Version1.0Date IssuedNov 2023AuthorE. WrightReviewed by: S. Barton-Jones / F. Van RonzelenDepartmentScience Schools Health & Safety TeamPage  PAGE 1 of  NUMPAGES \* MERGEFORMAT 12 GMO Risk Assessment PAGE 9 PAGE 8 )789  ; < = G H I M O U e i j k jh&U h!h&h!h&0Jjh&Ujh&Uh&h| h|CJ h sh|CJ aJ hhkh&6CJ(aJ( h&6CJ hY6CJ hh&5CJ(aJ(9899 : K L I J Y Z [ \ ] $$Ifa$$If gd&$a$gd&$a$$a$ gdY$a$gd&     6 7 8 9 : J O R Z ^ b h i k }    J K L V f h n    ' + 1 9 H I J hh&aJ h&aJh[h&aJhBp_h&0Jjh&Uh&PJ Q W X Y Z [ \ ] ^ _ ` a w x y z           ) * 5 6 h& hU h&hU h&h_ZCJh&h_Z5CJ h&CJ h&5CJP] ^ _ ` a \Jkd<$$Ifl03 K( 64 laytY $$Ifa$$IfJkd$$Ifl03 K( 64 laytY \Jkd$$Ifl03 K( 64 laytY $$Ifa$$IfJkd$$Ifl03 K( 64 laytY \Jkd$$Ifl03 K( 64 laytY $$Ifa$$IfJkdR$$Ifl03 K( 64 laytY \Jkd$$Ifl03 K( 64 laytY $$Ifa$$IfJkd$$Ifl03 K( 64 laytY       \JkdP$$Ifl03 K( 64 laytY $$Ifa$$IfJkd$$Ifl03 K( 64 laytY   5 6 D^kd$$IflK(064 laytY $$Ifa$gd&gd&Jkd$$Ifl03 K( 64 laytY6 B K L u ~  &'()*+,-./012345678?ABHIKLMhIh&5\ hH|5 h|5h|hh&5CJ aJ h& h&5S $a$gd&^kd$$IflK(064 laytY $$Ifa$ &'()*+,-./riiiiiiii $$Ifa$kd$$IflF' K(06    4 laytY $$Ifa$ /01234567KLrmmmg$Ifgd&kd$$IflF' K(06    4 laytY $$Ifa$ $If^kd$$IflK(064 laytY 3ckd $$Ifl4K(064 laf4ytY$Ifckd$$Ifl4zK(064 laf4ytY!",3456789LMlmowxyz{|}~   -<=?@IJKLTVWXyz{Ļж h}5 h|5h&h&CJ h|CJ hCJh| hCJ h|CJ h&CJ hIh&5\ h&5 hZh&h&F4563ckd. $$Ifl4K(064 laf4ytYckd $$Ifl4K(064 laf4ytY$If6789xy3ckd< $$Ifl4K(064 laf4ytYckd $$Ifl4QK(064 laf4ytY$Ifyz{|}~  KLz{gd&gd&ckd $$Ifl4QK(064 laf4ytY$If !%&'()1?T.<RUVWXYZcdhijkl  h}5h}huHX h!5 h"'i5 hj5hfh| h|5T':^kd $$IflK(064 laytY $Ifgd,a^kdJ $$IflK(064 laytY'();^kd $$IflK(064 laytY$If^kdD $$IflK(064 laytY42^kd$$IflK(064 laytY $Ifgd,a^kd>$$IflK(064 laytY$If $Ifgd,a^kd8$$IflK(064 laytY$IfU:82$If^kd2$$IflK(064 laytY $Ifgd"'i^kd$$IflK(064 laytYUVWXYZ4^kd,$$IflK(064 laytY $Ifgd,a$If^kd$$IflK(064 laytYZjkl2^kd&$$IflK(064 laytY$If^kd$$IflK(064 laytY $Ifgd,a^kd$$IflK(064 laytY $Ifgd,a$If89JKcv $$Ifa$gd}$ ? $Ifa$gd} ? $Ifgd}^kd $$IflK(064 laytY689:;@AEGIJKbcdemopwx(+,-. h"'i5ho?ho?56] ho?5h1@5CJ\aJh"'ih|5CJ\aJh5CJ\aJhh|5CJ\aJhh5CJ\aJh| h|5h}hqph}5CJ h}5CJ h}55cd;^kd$$IflK(064 laytY$If^kd$$IflK(064 laytY- $Ifgd,a^kd$$IflK(064 laytY$If-./01XYyyy $ ? $Ifa$ ? $Ifgdo? `^``^kd$$IflK(064 laytY ./01=BWXYbfz}~ "%-/78;JLMOPQTUVYZ[]^_vwxyz{ h|CJ h:hqpho?5CJ ho?5CJ ho?5h|56CJaJ h|CJh"'iho?h|LLM^_w $ ? $Ifa$ ? $Ifgdo?^kd$$IflK(064 laytYwxyz5 & F$Ifgd: $Ifgd:gdo?^kd$$IflK(064 laytY ,Eno(/123457LYv+,2567<xy h|5CJh|h:h|5h-h:5 h:5 h|5T$If^kd$$IflK(064 laytY67  $If  $Ifgd:  ^kd$$IflK(064 laytY #&')+DHQ_aghilsvyz ĺh,h:5aJ h,h:h,h:5CJh| hoLCJ h:5 h1@5 hoL5 h1@5CJh1@ h1@h1@I  $Ifqkd$$Ifl0!K(} 064 laytY QRSTUdttttgt dgd(/oTg dgd(/  dgd(/$  da$gd:  ^kd$$IflK(064 laytY GHOPQRSTUYZ[]^_`befghiopqrstuwxyz{|~ $&')*.3h,h:6]h,h:mHnHuh,h:>*h,h:>*mHnHu h,h:h,h:5aJL39HPQbdefghlmnpqrsuxyz{|"+?DGMOP[psth,h:mHnHuh,h:>*h,h:>*mHnHu h,h:h,h:6]Qdefghbcdefgfg ]gd: dgd(/oTg dgd(/_`abcdefgrvx|ùh,h:5aJh,h:\aJh,h:mHnHuh,h:>*h,h:>*mHnHu h,h:h,h:6]I  !"'+29KOdefghlm h:5CJh:h:OJQJh,h:6]h,h:mHnHuh,h:>*h,h:>*mHnHu h,h:Hgh349CH$If$a$gd:  gd: $  a$gd:gd:(0123489BCGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdeh:CJOJPJQJaJhnh:56 h:6h,h:\ h:5hnh:5h:jh:UmHnHuJHIJKL_YYY$Ifkd$$IfTlFb0 t06    44 lapTLMNOP_YYY$Ifkd/$$IfTlFb0 t06    44 lapTPQRST_YYY$Ifkd$$IfTlFb0 t06    44 lapTTUVWX_YYY$Ifkde$$IfTlFb0 t06    44 lapTXYZ[\_YYY$Ifkd$$IfTlFb0 t06    44 lapT\]^_`_YYY$Ifkd$$IfTlFb0 t06    44 lapT`abcd_YYY$Ifkd!$$IfTlFb0 t06    44 lapTdefgh_YYY$Ifkd$$IfTlFb0 t06    44 lapTefghijklmnopqrstuvwxyz{|}~±}}hYCJ^JaJhY5CJ^JaJh:0JmHnHu h:0Jjh:0JUhY hY5CJ,OJQJ\^JaJ,hY5OJQJ^J jh%OhYUmHnHuh jh Uh|h:h:CJOJPJQJaJ/hijkl_YYY$IfkdI$$IfTlFb0 t06    44 lapTlmnop_YYY$Ifkd$$IfTlFb0 t06    44 lapTpqrstvwy_ZQECCC $  a$gd:  gd:gd:kdq$$IfTlFb0 t06    44 lapTyz|}YW kd;$$If9o0~(AG   t8d0644 9ap8d$$7$8$Ifa$gdY  $7$8$IfgdY&`#$        " # - . S T U Z [ a b ̻ᰢ̑̑̑{lalh_shY0JCJjh_shY0JCJUh_shYCJhY5CJ\^JaJ h_shYCJ^JaJmH sH h:hYCJ\^JaJhYCJ\^JaJ hTg*hYCJ^JaJmH sH hYCJ^JaJmH sH h-\hYhY5CJ^JaJhYCJ^JaJhOpCCJ^JaJ$kd;$$Iflֈw^ LAK(NPV t0644 lap< # . T $7$8$IfgdYT U $a$gdYkd<$$Iflֈw^ LAK(NPV t0644 lap<b c d h i ˶xgggcc\RLBjhY0JU h|0Jjh|0JU hYhYhY hY5CJ,OJQJ\^JaJ,hY5OJQJ^J j=h%OhYUmHnHuh:hYh:CJ(jh_shY0JCJUmHnHuhYCJOJQJ^Jh_shYCJ%jh_shYCJOJQJU^Jh_shY0JCJjh_shY0JCJUhY0JCJ YWRgdY kdY$$If9o06AG   t8d0644 9ap8d$$7$8$Ifa$gdY hYhh0JmHnHuh| h|0Jjh|0JUhY0JmHnHu $  a$gd: &`#$ 2&P :pY. A!S"S#3$% 9&P 1F0:pYA .!"#$% / 0&P . A!"#$% @=3$Qo<س/ gZ|sGá$x ]Uu y$@_" &!AX|ɍ Mk>$_ԡ~ubX"Gq4"b 3:}{{^sν,6eg˲?Ͳ۲fYOvYYvJ^=2Sg{TQL?td-33u%3{{Uf6J gfU&:xtRŃ3G/\0xdS6s0k 3[(Vu/&r΀*hwLeteuO(ʲEYm3#׍+&"-qF[é҇wzREs „Fs 32hXm/DPU^! *TB'ҁC/+z.dgU*>'ѴKւ9<]2H_3?lb^o|=kSn/> V\;&>@*??'w3_Ed|eCX3_Qp=p%nDJG|^U/]eKu\Eq} |wd_HS}||L >uT4+u]d$Xnᛊy>w d|?x[?y][tO-Mgl/a(yy[ag.|wu~"M&|3pcV<1Q7o2_ >ij5<:!9"M6G'o*clO  &{??0#< 8Wc"mR3:uѰxWSI7ofD ߏyl>sclN- .~];w_-yZ:_8#ԝyO]~ݾ)_~g-_4Sf O|h?~o;|ψF<{;Wuf\^6̕B!{"ݾ@dY5suLcl`r1W]eϕAs帓A1WU_\+:2s'-"QfeِhXU 9Y1<d˳B.98gH,݆zFG/ VZlpuۘmQwGG`2ݬ~:w˴_( ƀ-e|nЁ,H9_csX<2bWVry1[%Q'+=[FM-ظ^W21} ˦j'g5bʗ1hukYbq.Pfq8׈{O;!v>ɊTqgDWƉedq>,{Sڳm2[}{oWڳe+%QPK|vmunU,S+"NqzRY9qu_o}ً` #2>0u:֩e-[ _:O}aY;_uy=xa Be#XgdDe{:lvv(v-h볳˾8<2&l!c_L/"ko܎'bjϲv:ه[:g;{_=W>vU,u25/V'7:A O}Au.DZ1oWx8O1(xue{l=쏩]˦b7bcj˲vU1F[%[Sڲز?Y}٢1`RPb?7,kow̸K~b,k',SxvCV?!IsTr^_y]"C³/zRƻ!!k{]ʓ9K~E+<{%vk{ty>ʁ雽2k¸bL2/Ŵʈ-Ԗlۡ-:ګÞ-ԖuwÉ׊4؉ekd5$>-kק}SI}Z֮e؉$>-kg\%:? QY?GxR;cKMƜJxׇDWRC|[wh(-ΥעՒ]SbMLVyn/Q>{#? $3?<ΓeJ<=L80O"#epOࣞpn >p~@y2w%[!doWZ }HU w+O1XFuQLWUw> WJ&"1VŲ2=4IC~u6ߨD'K)3hI֯Q5?&b96?#;;CR{Ѷ.sV|ܐ?A6gǫ;rMe/_uԕ}~ܿv6 ?J?zՆ-{];*^&V2]M5zoʙ_>ۢܵC~.:Gc(2$;x́"E+'-ӲK򽺳ue5 ƀ&blg\T"+]7Ѹ^_PWji$3jꏸxH̔-5koZ{Ւ="/(OX1esA{*n#i_ܼs꽗[bdDl2l)Jlz[q$2cqV̱{O6V htᲵ:\5eǫ%<ꛧ[tfd\q1OৎxZ'g=x P>Wt!ЋUyo߲^l\I 6!B~n&Ll ʘx#ݪp_Kp[F2Ò=K<~Sw ׅdU,c} j\yJq.HK뀨|D$`Y,%1xj-=*J4 t-Yv|Stdlw~ڟ_$o7~ցw?. BFe!F+;c}-}ŰnII N^N'qf㬼AqK (qZ#ڏXC],XެN ]sK3` `bϊ RCz֩\1}~(MX<7iF 2/˻?,[ݪ'kꢘ|٤vj> s|AY|̓xE|X.>ZŶw?㾂e6Eo֞װ&c^K i|X+m')pK4ޢr 1GecLc2L^½1nOyt5t/]7y1sS&^x}_Ǘ&|oya,wNQʝX~ꢘlPiVq~d5XO?)w(e.D4Nv)ѥ:Tdvd|f.w컈 ܗ5}e d4m.Za|بG=W3 ~raZ!t~ VdWJq~,'2l=sqƚ\<3l& }y/_aZf@[}qu&Z"UHbƲ]2%7d;wj 9~d~x.z=CWiXz)Èd~P)=|?/c{ b{V1J)H2q_x;Z>1^D['-2k%N]$I>ǔ8I \O12Ò&q~~U >q>}?W풍y>g9vŐX٧<ݧ,kOq2(SY,̑-cg|ccZ>!$4,뢘|ߩ3j6)ھ GO~zF$z]1Tw_zT~Ԑűoq%zEݩ߻j7ouŏwfW~W>}V#- []'-_O7z7-qu~7k6eEy򟈘_*G]Y>eWy%ҹB5y75{+[Wģ>.emkP~V|cW5?CWe=NDŽ>*ܯ_ZɲE3齪xz4 ;NO ϕZ[͒ sd#o}}R ؞1Ov8ےƉ}bG2o!~C>@9@Y+>ݕ9-Jc<=:TI.߾I+ FcqL}ogQW7#< \qrq>Un 6|0F#-]˃a-ߢtqt E'@oQ,{jFqرxn}N/>)sz3֎e5beX_.>Ѝ둲'ڱ}SuzqݣC!='(ӞDMQ }Fy:ꢘ/ "۲ \#1~CF[':lQh#Q:e|J[vY(ݺ?xd;b-i?*h$i!N]oU9+pLƝs+v)b㚚SAe|vq-QAmO #l#yH>"[ BE1oU/?{zr̷ dl8<&б t<^G똧_6'|kv"GWׅ\doaz.rc~.Rԅ>_X0OXUe,7j IeXQlGF1MjV-i;$MK׺tZƚ+]+o4X&:gy%>qi;Hj}LOG8 ,҉eB[szwY0 fbN:j=ytQɲcUS ]Q\zl1Q.$Us@G|,g=Vѯϖ\*|gK,k7p^¦)z࡬خ)\WyY_]kTy8^#Z9]ck"|;¦6O'"c2)&:(+jAznC$8duѰ=u JcL,ƒmHr\bcOvxb݉ml{'{ u\?^1"c=^/,]e4"1"s4tmP!\hAWQS-ASEl|ܶ*l[obs۪q݉;Ua;Wwm51bVkb)6 Ĉ Sln[G)6 7NmUظElbs۪q?wmH)6 -I>N٭w*ŷɴڸ+<Э「;UbW)6tĶ?)6tĖ+x+{!q|%.|>|-oyʞŷ†nn=n *g`+{ Ub=!St}v)6?Tj'><&eݷOl>k/*?YϜ'T]MD%Z( {ҥʗ.Yqg fKU<b6'j"l'6\ J5/wDyK yK bhttps://www.sussex.ac.uk/hso/hsoatozyX;H,]ą'cDyK yK https://www.hse.gov.uk/biosafety/gmo/acgm/acgmcomp/index.htmyX;H,]ą'cd$$If!vh#v #v:V l655 / 4ytYV$$If!vh#v #v:V l655 4ytYd$$If!vh#v #v:V l655 / 4ytYV$$If!vh#v #v:V l655 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytYd$$If!vh#v #v:V l655 / 4ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY$$If!vh#v #v :V l0654ytY$$If!vh#v #v :V l0654ytY{$$If!vh#v(:V l0654ytY$$If!vh#v(:V l4z0654f4ytY$$If!vh#v(:V l40654f4ytY$$If!vh#v(:V l40654f4ytY$$If!vh#v(:V l40654f4ytY$$If!vh#v(:V l4Q0654f4ytY$$If!vh#v(:V l40654f4ytY$$If!vh#v(:V l4Q0654f4ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY{$$If!vh#v(:V l0654ytY$$If!vh#v_"#vX:V l065}5 4ytY{$$If!vh#v(:V l0654ytY$$If!vh#v:V l t065/ pT$$If!vh#v:V l t065/ pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pT$$If!vh#v:V l t065pTDd 3  s PA?&Picture 1009539885"b<5v83kQa9YIn5v83kQa9YPNG  IHDRC'sRGBgAMA a pHYs.#.#x?vIDATx^흱~?)qa{.΀V[7ƕ*T@J:A]K \=;. s?w??}z7EORo VW݁pQ-<{Ͽ~6nn *>%^%Z@1ԿXyϮ PG~&ۏ<z*}gMO oQEsx`7ѽ=#Z<SyH`jCRNB$QDyʅ` i07۪^uc8f$xej0@`oe ^AӜԏͻMM8ĆSC~[SԟU1ܠ)$>lְ?5_ij.Kb٬?;yf^ӅXn< n+GG+Tg~ $3߶lhNysPۥON *v9; <{.fJIHbQ;C4NtTլ]5q6F#GzfwCg^7XlࣩwZ[ y*,GSZ=U?E :Yc͓iȏyPR8[{տ7ǚA?$9Ů6h]xȼpD9[RIAIGffѮN"k$7W3ShWgNZPoaj{x3\ L0ÏG}}:5l,AZG\ 0 B۵NWDj;c7u4 I:W3ShT?$yE :PMHvW3ShW^c> fѮVߥTIN: ::8r70t5doOoajwH| :1{p70{?>/.}4oaj+~"N֟uP?ȘLM : Zx-p70yɫu<"S2Y\ Lo]ɦ|ڳQW3Sx0a촫u<.hvNAZV,'bdW3SJ7<ߢt70 hma9joAZǶDV%ܖ3l] LcsxjE\p70XN<*OtW3SO߼e COYoaj{?8u|`)u8ɡЇT :W^f,-1XX5#M :ҏ/,ϢoajgP>? ߋFtuG >0,Za/38ݚ38ƬԮRcW7'0j9+W=<WSxE__Rw Z6fya￀o9Eۏ~oaw0z bAyS 6NIOGxCUxJt~d8&`^8N)lہ4|T7pgD@t_Xx<_yV ڋI c[2/nV%8:yA{h5WO?F#:F`[m|zE_;} G>u0e?١=a> 8q>2ρJ?hkxUPJ'*Mzhs$xwDw U%9ɁɫNfBǟX-Ǽ~_}߄ {3ZNOWӕxqяFz5<7QRsK6r}^ԭ#V?8r r-nUz]n[ j'c*_y. vĜ#b]Γ~s  9Gu,E4\PNsVƜ:⏻ q~1uP^eú!u\i>;r07R~9@;T?>uEG* u Ε>8YG> %g\4n!CWtu\?HVK5QCM0A]?8h.}m,O>8_"_THP~l6~"; ClyTm`a̅ 1c3Qw8j X.uZ fQ?`Lf]'m΀x 'd 1+N ,d &R? 0 no2yթB[aȼc^̥~0Uu%N/ 'K'Q?d-hl,V0Q{4W~Ⱥ(BݜGԽOT 0UB=`~!h$O~XZhp)V m*I2M BQw!.O>Ԣ<I^ &aLZ^%P0_"l}Հ<RtmZR80^-@=:od@iI=δM xu *{D:KYM:77 :Jg0[5cKꇫGW7{|iSAiZy+0UPި՟ 61iyFϵhbq3|!=X5~DHe'Bj-k))xN*RPHmWS>?׍2eS\^@%ZRy?wx03\86ϗh\ A`5_@+enTXۭt QQܢng+&c v2ː7:: Wp; Wp; Wp; Wp; Wp; Wp; Wp;Cm+~@'fOޅ?ع nZP~=я>4~ƚʼnQ^&YJj4^B:d'P \/v&T,Csg7VIOATT0֬[~A@* o.Cm{V~7R1Da$hY>㋹@[@Բ0֬,MNm+,wǍTZ>;qʱCDlbLT0MATuaP' )nA}:;KAM'\co 1!M:CN) &cϕ!{z{kzu: y\4ygqfGg*UQOdd*XՏ#x}qKpbvKa#,UH+9#s\Pzi\Tq'K%Ezo7Lpcl7`U8y! H jiiF߰[?-HIpQ46t,~ F8%0QN p]Q^nQ2^|6EcAo\ū7O@,V0J,] s5νcQ2^|G`o+% 87Z ?LkIb#bFI('i1x$G',]-YIC`@ÎxSlI˳(W@^Rb1h~$u!a| AVF#k&0_LFiRodŨX""U"fi1xqR2xq%PWV0D1M4f2m>Cu:SKAySXq@D;0=?۩/E YtP?`<-'bq%IXs ԿVqG% x*Q]tR%k+?@%;uä~aei72b S5, AX!CW/@,Y'؇q.W?WJ̣rZ͛ &3 5r!-3oX(S¶35R\;oa>]rW/fIKMĈE 5%a!u@iJEXdIaBXD$ߛHJ~bZEccƩܶyaU?[<?jkS/_"2\UPjRSzbJ x#C յ+Ƹ4a8h ߞbm>v\K C>2!2 {Oaɝ(iJb>\0I )O~ oZyw"z)ء~+Jy\HB>1XN%b!Qxa0ru c#_"S:L_~ KFR2M;qȊ Q+^xSWP=@lRosnN_[3ȩJ%!Q}<*R n`F-")(@]%saXL_[ 6eqb{zn' ǫW)";&c5AR\68C%t+mv4THx<4잯?_7mpj,IENDB`$$If!vh#v#v!:V 9o   t8d06,5A5G/ 4 9p8d$$If!vh#v#v#v#vk#v#v :V l t065N5P5555Vp<$$If!vh#v#v#v#vk#v#v :V l t065N5P5555Vp<Dd 3  s PA?&Picture 1009539885"b<5v83kQa9Y>n5v83kQa9YPNG  IHDRC'sRGBgAMA a pHYs.#.#x?vIDATx^흱~?)qa{.΀V[7ƕ*T@J:A]K \=;. s?w??}z7EORo VW݁pQ-<{Ͽ~6nn *>%^%Z@1ԿXyϮ PG~&ۏ<z*}gMO oQEsx`7ѽ=#Z<SyH`jCRNB$QDyʅ` i07۪^uc8f$xej0@`oe ^AӜԏͻMM8ĆSC~[SԟU1ܠ)$>lְ?5_ij.Kb٬?;yf^ӅXn< n+GG+Tg~ $3߶lhNysPۥON *v9; <{.fJIHbQ;C4NtTլ]5q6F#GzfwCg^7XlࣩwZ[ y*,GSZ=U?E :Yc͓iȏyPR8[{տ7ǚA?$9Ů6h]xȼpD9[RIAIGffѮN"k$7W3ShWgNZPoaj{x3\ L0ÏG}}:5l,AZG\ 0 B۵NWDj;c7u4 I:W3ShT?$yE :PMHvW3ShW^c> fѮVߥTIN: ::8r70t5doOoajwH| :1{p70{?>/.}4oaj+~"N֟uP?ȘLM : Zx-p70yɫu<"S2Y\ Lo]ɦ|ڳQW3Sx0a촫u<.hvNAZV,'bdW3SJ7<ߢt70 hma9joAZǶDV%ܖ3l] LcsxjE\p70XN<*OtW3SO߼e COYoaj{?8u|`)u8ɡЇT :W^f,-1XX5#M :ҏ/,ϢoajgP>? ߋFtuG >0,Za/38ݚ38ƬԮRcW7'0j9+W=<WSxE__Rw Z6fya￀o9Eۏ~oaw0z bAyS 6NIOGxCUxJt~d8&`^8N)lہ4|T7pgD@t_Xx<_yV ڋI c[2/nV%8:yA{h5WO?F#:F`[m|zE_;} G>u0e?١=a> 8q>2ρJ?hkxUPJ'*Mzhs$xwDw U%9ɁɫNfBǟX-Ǽ~_}߄ {3ZNOWӕxqяFz5<7QRsK6r}^ԭ#V?8r r-nUz]n[ j'c*_y. vĜ#b]Γ~s  9Gu,E4\PNsVƜ:⏻ q~1uP^eú!u\i>;r07R~9@;T?>uEG* u Ε>8YG> %g\4n!CWtu\?HVK5QCM0A]?8h.}m,O>8_"_THP~l6~"; ClyTm`a̅ 1c3Qw8j X.uZ fQ?`Lf]'m΀x 'd 1+N ,d &R? 0 no2yթB[aȼc^̥~0Uu%N/ 'K'Q?d-hl,V0Q{4W~Ⱥ(BݜGԽOT 0UB=`~!h$O~XZhp)V m*I2M BQw!.O>Ԣ<I^ &aLZ^%P0_"l}Հ<RtmZR80^-@=:od@iI=δM xu *{D:KYM:77 :Jg0[5cKꇫGW7{|iSAiZy+0UPި՟ 61iyFϵhbq3|!=X5~DHe'Bj-k))xN*RPHmWS>?׍2eS\^@%ZRy?wx03\86ϗh\ A`5_@+enTXۭt QQܢng+&c v2ː7:: Wp; Wp; Wp; Wp; Wp; Wp; Wp;Cm+~@'fOޅ?ع nZP~=я>4~ƚʼnQ^&YJj4^B:d'P \/v&T,Csg7VIOATT0֬[~A@* o.Cm{V~7R1Da$hY>㋹@[@Բ0֬,MNm+,wǍTZ>;qʱCDlbLT0MATuaP' )nA}:;KAM'\co 1!M:CN) &cϕ!{z{kzu: y\4ygqfGg*UQOdd*XՏ#x}qKpbvKa#,UH+9#s\Pzi\Tq'K%Ezo7Lpcl7`U8y! H jiiF߰[?-HIpQ46t,~ F8%0QN p]Q^nQ2^|6EcAo\ū7O@,V0J,] s5νcQ2^|G`o+% 87Z ?LkIb#bFI('i1x$G',]-YIC`@ÎxSlI˳(W@^Rb1h~$u!a| AVF#k&0_LFiRodŨX""U"fi1xqR2xq%PWV0D1M4f2m>Cu:SKAySXq@D;0=?۩/E YtP?`<-'bq%IXs ԿVqG% x*Q]tR%k+?@%;uä~aei72b S5, AX!CW/@,Y'؇q.W?WJ̣rZ͛ &3 5r!-3oX(S¶35R\;oa>]rW/fIKMĈE 5%a!u@iJEXdIaBXD$ߛHJ~bZEccƩܶyaU?[<?jkS/_"2\UPjRSzbJ x#C յ+Ƹ4a8h ߞbm>v\K C>2!2 {Oaɝ(iJb>\0I )O~ oZyw"z)ء~+Jy\HB>1XN%b!Qxa0ru c#_"S:L_~ KFR2M;qȊ Q+^xSWP=@lRosnN_[3ȩJ%!Q}<*R n`F-")(@]%saXL_[ 6eqb{zn' ǫW)";&c5AR\68C%t+mv4THx<4잯?_7mpj,IENDB`$$If!vh#v( #v-:V 9o   t8d06,5A5G/ 4 9p8d#x666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666_HmH nH sH tH <`< NormalCJ_HmH sH tH >>  Heading 1$$@&a$58@8  Heading 2$@&5B@B  Heading 3$$@&a$5CJ <<  Heading 4$@&5CJ>>  Heading 5$$@&a$5<@<  Heading 6$@&5CJ DA`D Default Paragraph FontVi@V 0 Table Normal :V 44 la (k ( 0No List 6J6 Subtitle$a$68B8  Body Text$a$54>4 Title$a$5CJ JP"J Body Text 2 ]5CJOJQJ@Q2@  Body Text 3$a$5CJ0U`A0 Hyperlink>*B*4 @R4 "Footer  9r .)@a. Page NumberFV qF FollowedHyperlink >*B* phHH  Balloon TextCJOJQJ^JaJ@ @j0RevisionCJ_HmH sH tH Rv!R j0Unresolved MentionB*ph`^\q B' B "t0Comment ReferenceCJaJ88 "t0 Comment TextCJ:: "t0Comment Text Char@j@ "t0Comment Subject5\F/F "t0Comment Subject Char5\4@4 !Y0Header B#6/6 Y0 Header CharCJtH 6/!6 Y Footer CharCJtH PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vj\{cp/IDg6wZ0s=Dĵw %;r,qlEآyDQ"Q,=c8B,!gxMD&铁M./SAe^QשF½|SˌDإbj|E7C<bʼNpr8fnߧFrI.{1fVԅ$21(t}kJV1/ ÚQL×07#]fVIhcMZ6/Hߏ bW`Gv Ts'BCt!LQ#JxݴyJ] C:= ċ(tRQ;^e1/-/A_Y)^6(p[_&N}njzb\->;nVb*.7p]M|MMM# ud9c47=iV7̪~㦓ødfÕ 5j z'^9J{rJЃ3Ax| FU9…i3Q/B)LʾRPx)04N O'> agYeHj*kblC=hPW!alfpX OAXl:XVZbr Zy4Sw3?WӊhPxzSq]y hMM4Mo %2..00000=JLLO J 6 .3eb !%/369<=?@BKQUW]  /6y'UZc-wdgHLPTX\`dhlpyT  "#$&'()*+,-.0124578:;>ACDEFGHIJLMNOPRSTVX <Gi6XXX%,.079=DFO!T!!!tt ,"$Qo<س/ g;$n*@ (  V  3 A #" `?B S  ?H0(  9t _Hlt149045343 _Hlt149045344 _Hlt149045347 _Hlt149045348 _Hlk150177787 _Hlk150178170 _Hlk150338414 _Hlk149045650 _Hlk149045716 _Hlk147139574 _Hlk150166424 _Hlk150337411 _Hlk149063946 _Hlk149063987 _Hlk149063998 _Hlk149064016 _Hlk149064050 _Hlk149064035 _Hlk149064086 _Hlk149064146 _Hlk150166654 _Hlk150857966AALLY Uhbgfhh@@@@ BBHI} x Pdgfhrrtvwyz|} 8@tvwyz|}333J 6L )  Z l 9 d Y M z o4rstvwyz|}#.U8JKKLTVWXy  V W d d b d d e m o p w x  . / 1 = X z nstCf;Jh ^`hH.h ^`hH.h pL^p`LhH.h @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PL^P`LhH.Cf;         65CU 1@ sh -Im.(/o?OpCoL{L NuHXurg"'iGoPrvDxRx|nz_,afH|Y&|&j(}a,V [m)UwD /$"t Eh:2tLiF!tv@@Unknown Edward WrightG.[x Times New Roman5Symbol3. .[x Arial3.[x Times7..{$ Calibri5..[`)TahomaC.,.{$ Calibri LightA$BCambria Math"h#'#'zF * *!20ii KQ@P  $Purg2!xx)X! Cardiff UniversityINFOS Kirsty Hart Oh+'0|   , 8 D P\dltCardiff UniversityINFOSNormal Kirsty Hart2Microsoft Office Word@F#@Rf@&@&  ՜.+,D՜.+,\ px  Data Doctors* i Cardiff University Titlet(\d( _PID_HLINKSGrammarlyDocumentIdAh)mailto:safetyscienceschools@sussex.ac.uk=https://www.hse.gov.uk/biosafety/gmo/acgm/acgmcomp/index.htm%https://www.sussex.ac.uk/hso/hsoatozDb700495550db69988d6c5c4cd36d220af7e30653bbdda1bd26392d2790b6aef1  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijkmnopqrstuvwxyz{|}~Root Entry F ڙ&Data lZ1Table1WordDocumentSummaryInformation(DocumentSummaryInformation8CompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q